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Data analysis shows that adopting therapeutic changes can lead to a longer lifespan




Data analysis shows that adopting therapeutic changes can lead to a longer lifespan

PCAge testing for robustness and precision. a, Ridgeline plots of male and female populations binned by decade for CA. b, Scatterplot and linear regression of PhenoAge versus PCAge for men and women. c, Impact of random errors in clinical parameters on BA clocks and disease score. d, Kaplan-Meier survival curves over 20 years of follow-up for subjects with PhenoAges aged 55–64 years, stratified by PCAge or PhenoAge. e, Equivalent to d but with Kaplan-Meier survival curves for subjects with PCA ages 55–64 years. Credit: Nature aging (2024). DOI: 10.1038/s43587-024-00646-8

A combined team of longevity specialists, gerontologists and biochemists from Singapore General Hospital, National University of Singapore and Yale-NUS College, Singapore, has found that people who take the right steps to promote their longevity can live longer if they follow certain guidelines. to follow.

In their studypublished in the magazine Nature agingthe group analyzed aging-related data from various sources.

In recent years, medical researchers have come to believe that people have both a chronological and a biological age. The first is determined annually and works the same for everyone. The latter depends on a large number of factors, most of which are based on hereditary, environmental and lifestyle choices.

For years, the medical community has believed that people who choose to make certain changes in the way they live can extend their lifespan by, for example, eating healthier foods, exercising and avoiding dangerous activities. For this new study, the researchers looked for concrete evidence showing that such assumptions are correct.

The researchers analyzed training datasets from the National Health and Nutrition Examination Survey containing medical information for 1,476 men and 1,536 women between the ages of 40 and 84.

They documented the results for people who had undergone treatment for diseases or conditions known to affect lifespan, such as heart and kidney problems and/or conditions that cause chronic inflammation, and compared them with those who had not. They found close agreement between the two aging benchmarks, although they noted that there were some significant residuals.

The researchers then compared what they describe as a streamlined aging clock to what they describe as a clinical aging clock. They found that they both performed in similar ways when used to measure a given person’s likely lifespan. They also found that both were better predictors of longevity than chronological age clocks.

The team then looked at data from the CALERIE study, which examined the impact of a restricted diet on longevity, and found that just two years of following the diet led to a significant reduction in biological age.

More information:
Sheng Fong et al., Component-based clinical aging clocks identify hallmarks of healthy aging and targets for clinical intervention, Nature aging (2024). DOI: 10.1038/s43587-024-00646-8

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